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Methemoglobinemia

By Ilene B. Anderson, PharmD; and Susan Y. Kim, PharmD

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Diagnosis

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One of the most important clues in diagnosing Mhgb is when a cyanotic patient shows no clinical improvement despite 100% oxygen administration. As noted above, even at relatively low levels of Mhgb, the patient may have a cyanotic appearance, yet have no clinical symptoms. Whether at low or high methemoglobin levels, administration of 100% oxygen will not result in any clinical improvement of cyanosis nor increase the oxygen-carrying capacity of the blood to any substantive degree.


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