Ventilator - Induced Lung Injury

By Neil R. MacIntyre, MD, FCCP

Figure 1

Lung injury induced by high ventilatory pressures in a rat model. The lung on the left received normal ventilatory pressures. The lung on the right received ventilatory pressures exceeding normal maximal transpulmonary pressures. The lung in the middle also received excessive ventilatory pressures but received PEEP, in addition. Note the severe injury induced by excessive pressures and how it can be attenuated with PEEP. (Reprinted with permission from Webb and Tierney)

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