Single vs Multiple Antibiotics in Community-Acquired Pneumonia

By Richard G. Wunderink, MD, FCCP; and Grant W. Waterer, MBBS, FCCP

Figure 4 compares actual and APACHE II-predicted mortality rates for the most common single-drug and combination therapies in the two groups. Rather than excess mortality compared with predicted in the monotherapy group, dual therapy was associated with lower mortality than predicted, especially for the cephalosporin/macrolide and the quinolone/vancomycin combinations.

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