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Lessons by Volume

Thrombophilia: How To Test? How To Manage?

By Julie Hambleton, MD

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**Table 2—***Primary Causes of Venous Thromboembolic Disease*
Deficiencies of the Natural Inhibitors
AT deficiency PC deficiency Heterozygous autosomal dominant Homozygous autosomal recessive PS deficiency
Qualitative Abnormalities of Hemostatic Regulatory Proteins
Factor V Leiden mutation Prothrombin 20210
Qualitative Abnormalities of Fibrinogen
Dysfibrinogenemia
Defects in the Fibrinolytic System With Impaired Clot Lysis
Rare; poorly characterized
Other (Unknown Mechanism)
Persistently elevated factor VIII

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