Mesothelioma Update

By Mark Block, MD; and Alice M. Boylan, MD

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Newer Agents Under Study

Ranpirnase [onconase (p30)] is a ribonuclease inhibitor that has been shown to have activity in this disease.²⁸ A multicenter trial is currently in progress using onconase in combination with doxorubicin vs doxorubicin alone.

Other agents undergoing clinical investigation for treatment of mesothelioma include ZD 1839 (Iressa), an epidermal growth factor inhibitor; antimesothelin monoclonal antibody toxin (the antibody carrys a potent cytotoxic agent that attaches to the mesothelin antigen on tumor cells); and antineoplastons (peptides found in the blood and urine of man with antitumor effects).

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