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COVID-19: Research

The CHEST COVID-19 Task Force curates key emerging research deemed to be helpful to clinicians on the front lines. Articles are listed by category in reverse order of publication date, are freely available, and link to the publication site. This list will be maintained regularly. Suggestions for consideration can be sent to COVID-19@chestnet.org.

Clinical Management

Epidemiology

Public Health and Systems Issues

Science

Clinical Management

A Trial of Lopinavir–Ritonavir in Adults Hospitalized With Severe COVID-19
NEJM (March 18, 2020)

Severe Outcomes Among Patients With Coronavirus Disease 2019 (COVID-19) — United States, February 12–March 16, 2020
Mortality and Morbidity Weekly Report (March 18, 2020)

Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
JAMA (March 13, 2020)

Detection of SARS-CoV-2 in Different Types of Clinical Specimens
JAMA (March 11, 2020)

The Incubation Period of Coronavirus Disease 2019 (COVID-19) From Publicly Reported Confirmed Cases: Estimation and Application
Annals of Internal Medicine (March 10, 2020)

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Clinical Infectious Disease (March 9, 2020)

COVID-19 and the Cardiovascular System
Nature Reviews Cardiology (March 5, 2020)

Chloroquine and Hydroxychloroquine as Available Weapons to Fight COVID-19
International Journal of Microbial Agents (March 4, 2020)

Severe SARS-CoV-2 Infections: Practical Considerations and Management Strategy for Intensivists
Intensive Care Medicine (February 26, 2020)

Clinical Course and Outcomes of Critically Ill Patients With SARS-CoV-2 Pneumonia in Wuhan, China: A Single-Centered, Retrospective, Observational Study
Lancet Respiratory (February 24, 2020)

Preparing for the Most Critically Ill COVID-19 Patients: The Potential Role of ECMO
JAMA (February 19, 2020)

Baricitinib as Potential Treatment for 2019-nCoV Acute Respiratory Disease
Lancet (February 15, 2020)

Epidemiology

A Novel Coronavirus (COVID-19) Outbreak: A Call for Action
CHEST (February 19, 2020)

Epidemiological and Clinical Characteristics of 99 Cases of 2019 Novel Coronavirus Pneumonia in Wuhan, China: A Descriptive Study.
Lancet (February 15, 2020)

Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus–Infected Pneumonia
NEJM (January 29, 2020)

Public Health and Systems Issues

Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response
JAMA (March 13, 2020)

Staff Safety During Emergency Airway Management for COVID-19 in Hong Kong
Lancet Respiratory (February 24, 2020)

Science

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Cell (March 5, 2020)