CHESTGuidelines & Topic CollectionsUnderstanding the Mechanisms of Refractory Chronic Cough

Understanding the Mechanisms of Refractory Chronic Cough

About this video

Released May 2026

This animated video traces the neurobiological pathways that drive refractory chronic cough (RCC), from peripheral sensory activation to central cough hypersensitivity. Gain a visual foundation for understanding why the cough reflex becomes dysregulated in patients with RCC and how emerging therapeutic targets, including the ATP-P2X3 signaling pathway, are informing a new generation of treatment approaches.

This webinar is part of CHEST’s Bridging Specialties®: Timely Diagnosis and Treatment for Refractory Chronic Cough program.

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This activity is supported in whole through an unrestricted educational grant from GSK.


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