Sepsis research, news, and notes

Additional research in sepsis

Review other important research in sepsis selected by members of the Sepsis Resources Steering Committee, including studies exploring performance improvement programs for sepsis and sepsis early warning systems.


News, notes, and opinions in sepsis medicine


The pendulum swings in favor of corticosteroids
This article provide an update on trials and guidelines that consider how low-dose corticosteriods impact mortality in adults with septic shock.

Now we have MERCY
MERCY adds to the existing body of evidence suggesting that prolonged and intermittent infusion strategies for meropenem are at least equivalent in efficacy.

We need more efforts to prevent sepsis readmissions
Though sepsis is not a direct readmission measure, it could be one in the future.


Hospital-onset sepsis: Why the brouhaha?
Authors highlight the importance of prompt identification and treatment of HOS within the first few hours of onset and regular reevaluation of the patient’s response.

Complexity of hemodynamic assessment in patients with cirrhosis and septic shock
In patients with decompensated cirrhosis, there are multiple intrahepatic and extrahepatic factors contributing to hemodynamic alterations at baseline.

Sepsis-induced cardiomyopathy: Is it time to establish a standard of care?
Sepsis-induced cardiomyopathy (SICM) complicates greater than 10% of sepsis and septic shock cases. But no universal definition of SICM exists, making diagnosis and evaluation of novel therapeutic options difficult.


The mission of the Sepsis Resources Steering Committee—made up of leaders from the CHEST membership with a clinical expertise in sepsis management—is to curate a collection of resources designed to help guide and inform the care clinicians deliver to patients with sepsis. This committee aims to provide clinicians with the latest guidance and research to help enhance sepsis prevention practices and improve patient outcomes.

Steven Q. Simpson, MD, FCCP, Chair

Steven Q. Simpson,
MD, FCCP, Chair

CHEST President, 2020-2021

Christopher Carroll, MD, FCCP

Christopher Carroll,

Angel Coz Yataco, MD, FCCP

Angel Coz Yataco,

Alice Gallo De Moraes, MD, FCCP

Alice Gallo De Moraes,

Ryan Maves, MD, FCCP

Ryan Maves,

H. Bryant Nguyen, MD, MS

H. Bryant Nguyen,

Katie Pendleton, MD, FCCP

Katie Pendleton,

Marcos Restrepo, MD, PhD, FCCP

Marcos Restrepo,

These resources were supported by Grant/Cooperative Agreement Number 5 NU50CK000604-02-00 from the Department of Health and Human Services, Centers for Disease Control and Prevention. The contents are solely the responsibility of the authors and do not necessarily represent the official views of the Department of Health and Human Services, Centers for Disease Control and Prevention.